Assay Detail
Binding
CHEMBL877833
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Inhibitory activity towards group 2 metabotropic glutamate receptor by displacement of ACPD-sensitive [3H]- glutamate in rat forebrain membrane
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Forebrain |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
(2S,4S)-amino-4-(2,2-diphenylethyl)pentanedioic acid selective group 2 metabotropic glutamate receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.41 | 6.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL40123 | — | — | 1 | 6.42 |
| CHEMBL350704 | — | — | 1 | 5.94 |
| CHEMBL352773 | — | — | 1 | 5.85 |
| CHEMBL351653 | — | — | 1 | 5.74 |
| CHEMBL165500 | — | — | 1 | 5.60 |
| CHEMBL351946 | — | — | 1 | 5.50 |
| CHEMBL353121 | — | — | 1 | 5.50 |
| CHEMBL166309 | — | — | 1 | 5.48 |
| CHEMBL39338 | — | — | 1 | 5.47 |
| CHEMBL168017 | — | — | 1 | 5.47 |
| CHEMBL348985 | — | — | 1 | 5.34 |
| CHEMBL442712 | — | — | 1 | 5.33 |
| CHEMBL353124 | — | — | 1 | 5.33 |
| CHEMBL350497 | — | — | 1 | 5.11 |
| CHEMBL424016 | — | — | 1 | 5.05 |
| CHEMBL349277 | — | — | 1 | 5.05 |
| CHEMBL164132 | — | — | 1 | 5.03 |
| CHEMBL423104 | — | — | 1 | 4.84 |
| CHEMBL305387 | — | — | 1 | 4.68 |
| CHEMBL164614 | — | — | 1 | - |
| CHEMBL165544 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL40123 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL350704 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL352773 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL351653 | — | IC50 | = | 1840.0 | nM | 5.74 |
| CHEMBL165500 | — | IC50 | = | 2490.0 | nM | 5.60 |
| CHEMBL351946 | — | IC50 | = | 3160.0 | nM | 5.50 |
| CHEMBL353121 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL166309 | — | IC50 | = | 3330.0 | nM | 5.48 |
| CHEMBL39338 | — | IC50 | = | 3380.0 | nM | 5.47 |
| CHEMBL168017 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL348985 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL442712 | — | IC50 | = | 4650.0 | nM | 5.33 |
| CHEMBL353124 | — | IC50 | = | 4690.0 | nM | 5.33 |
| CHEMBL350497 | — | IC50 | = | 7850.0 | nM | 5.11 |
| CHEMBL424016 | — | IC50 | = | 8990.0 | nM | 5.05 |
| CHEMBL349277 | — | IC50 | = | 8820.0 | nM | 5.05 |
| CHEMBL164132 | — | IC50 | = | 9280.0 | nM | 5.03 |
| CHEMBL423104 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL305387 | — | IC50 | = | 21100.0 | nM | 4.68 |
| CHEMBL164614 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL165544 | — | IC50 | > | 100000.0 | nM | - |