Compound Detail
CHEMBL305387
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL305387 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WXUSMGPIDBQKHZ-NEPJUHHUSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
265.3
MW (Da)
1.51
ALogP
3
HBA
3
HBD
100.6
PSA (Ų)
0.66
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.68
Ki 1 meas. best 5.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, kainate 1 CHEMBL1918 | Ki | 5.92 | 5.92 | 1190.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 4.68 | 4.68 | 21100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, kainate 1 | Ki | = | 1190.0 | nM | 5.92 | Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 ... | 10821708 |
| Unchecked | IC50 | = | 21100.0 | nM | 4.68 | Inhibitory activity towards group 2 metabotropic glutamate receptor by displacem... | 9871538 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10821708 | 10.1021/jm9911682 | Glutamate receptor ionotropic, kainate 1 | 1 |
| 10821708 | 10.1021/jm9911682 | Glutamate receptor ionotropic, kainate 2 | 1 |
| 10821708 | 10.1021/jm9911682 | Unchecked | 1 |
| 9871538 | 10.1016/s0960-894x(98)00091-2 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine