Assay Detail
Functional
CHEMBL878021
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Negative logarithm of the molar concentration required to relax rat aorta precontracted with 30 mM KCl by 50% of IA
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure-activity relationships of 6-substituted benzopyran-4-carbothioamide potassium channel openers
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 7.36 | 8.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL297457 | — | — | 1 | 8.87 |
| CHEMBL45322 | — | — | 1 | 8.69 |
| CHEMBL44369 | — | — | 1 | 8.39 |
| CHEMBL44370 | — | — | 1 | 8.03 |
| CHEMBL296891 | — | — | 1 | 7.90 |
| CHEMBL45368 | — | — | 1 | 7.72 |
| CHEMBL45314 | — | — | 1 | 7.61 |
| CHEMBL295351 | — | — | 1 | 7.43 |
| CHEMBL46485 | — | — | 1 | 7.02 |
| CHEMBL49035 | CROMAKALIM | 2.0 | 1 | 6.77 |
| CHEMBL417178 | — | — | 1 | 6.49 |
| CHEMBL46994 | — | — | 1 | 6.38 |
| CHEMBL298309 | — | — | 1 | 6.34 |
| CHEMBL42605 | — | — | 1 | 5.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL297457 | — | EC50 | = | 1.349 | nM | 8.87 |
| CHEMBL45322 | — | EC50 | = | 2.042 | nM | 8.69 |
| CHEMBL44369 | — | EC50 | = | 4.074 | nM | 8.39 |
| CHEMBL44370 | — | EC50 | = | 9.333 | nM | 8.03 |
| CHEMBL296891 | — | EC50 | = | 12.59 | nM | 7.90 |
| CHEMBL45368 | — | EC50 | = | 19.05 | nM | 7.72 |
| CHEMBL45314 | — | EC50 | = | 24.55 | nM | 7.61 |
| CHEMBL295351 | — | EC50 | = | 37.15 | nM | 7.43 |
| CHEMBL46485 | — | EC50 | = | 95.5 | nM | 7.02 |
| CHEMBL49035 | CROMAKALIM | EC50 | = | 169.82 | nM | 6.77 |
| CHEMBL417178 | — | EC50 | = | 323.59 | nM | 6.49 |
| CHEMBL46994 | — | EC50 | = | 416.87 | nM | 6.38 |
| CHEMBL298309 | — | EC50 | = | 457.09 | nM | 6.34 |
| CHEMBL42605 | — | EC50 | = | 4265.8 | nM | 5.37 |