Assay Detail
Binding
CHEMBL878025
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The competitive inhibitory activity against trypanothione reductase was evaluated from Lineweaver Burk plots
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma cruzi |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibition of Trypanosoma cruzi trypanothione reductase by acridines: kinetic studies and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 4.73 | 5.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL151228 | — | — | 1 | 5.26 |
| CHEMBL76954 | — | — | 1 | 5.16 |
| CHEMBL153790 | — | — | 1 | 5.00 |
| CHEMBL151397 | — | — | 1 | 4.96 |
| CHEMBL7568 | QUINACRINE | 4.0 | 1 | 4.72 |
| CHEMBL152023 | — | — | 1 | 4.57 |
| CHEMBL43184 | AMINACRINE | 2.0 | 1 | 4.42 |
| CHEMBL146512 | — | — | 1 | 4.37 |
| CHEMBL292314 | — | — | 1 | 4.10 |
| CHEMBL95 | TACRINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL151228 | — | Ki | = | 5500.0 | nM | 5.26 |
| CHEMBL76954 | — | Ki | = | 7000.0 | nM | 5.16 |
| CHEMBL153790 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL151397 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL7568 | QUINACRINE | Ki | = | 19000.0 | nM | 4.72 |
| CHEMBL152023 | — | Ki | = | 27000.0 | nM | 4.57 |
| CHEMBL43184 | AMINACRINE | Ki | = | 38000.0 | nM | 4.42 |
| CHEMBL146512 | — | Ki | = | 43000.0 | nM | 4.37 |
| CHEMBL292314 | — | Ki | = | 80000.0 | nM | 4.10 |
| CHEMBL95 | TACRINE | Ki | = | 140000.0 | nM | - |