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Assay Detail

CHEMBL878030

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity for cholesterol 17-alpha-hydroxylase
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Steroid 17-alpha-hydroxylase/17,20 lyase (CHEMBL3522)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering.
Walker KA, Kertesz DJ, Rotstein DM, Swinney DC, Berry PW, So OY, Webb AS, Watson DM, Mak AY, Burton PM.
J Med Chem (1993) 36 : 2235 -2237
PubMed 8340925 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 6.96 6.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL305220 1 6.96

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL305220 Ki = 109.0 nM 6.96