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Assay Detail

CHEMBL878130

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Binding
Inhibitory activity against Monoamine oxidase B
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Amine oxidase [flavin-containing] B (CHEMBL2993)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Molecular determinants of MAO selectivity in a series of indolylmethylamine derivatives: biological activities, 3D-QSAR/CoMFA analysis, and computational simulation of ligand recognition.
Morón JA, Campillo M, Perez V, Unzeta M, Pardo L.
J Med Chem (2000) 43 : 1684 -1691
PubMed 10794685 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 21 6.41 9.12

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL45069 1 9.12
CHEMBL298006 1 8.52
CHEMBL46952 1 8.40
CHEMBL44430 1 7.82
CHEMBL416467 1 7.52
CHEMBL46898 1 7.52
CHEMBL44433 1 6.43
CHEMBL45765 1 6.09
CHEMBL46491 1 5.42
CHEMBL298491 1 5.06
CHEMBL44389 1 5.05
CHEMBL46602 1 4.32
CHEMBL48556 1 4.30
CHEMBL46601 1 4.22
CHEMBL47667 1 -
CHEMBL441241 1 -
CHEMBL46600 1 -
CHEMBL44487 1 -
CHEMBL45511 1 -
CHEMBL43727 1 -
CHEMBL45768 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL45069 Ki = 0.75 nM 9.12
CHEMBL298006 Ki = 3.0 nM 8.52
CHEMBL46952 Ki = 4.0 nM 8.40
CHEMBL44430 Ki = 15.0 nM 7.82
CHEMBL416467 Ki = 30.0 nM 7.52
CHEMBL46898 Ki = 30.0 nM 7.52
CHEMBL44433 Ki = 370.0 nM 6.43
CHEMBL45765 Ki = 820.0 nM 6.09
CHEMBL46491 Ki = 3830.0 nM 5.42
CHEMBL298491 Ki = 8800.0 nM 5.06
CHEMBL44389 Ki = 8900.0 nM 5.05
CHEMBL46602 Ki = 48000.0 nM 4.32
CHEMBL48556 Ki = 50000.0 nM 4.30
CHEMBL46601 Ki = 60000.0 nM 4.22
CHEMBL47667 Ki = 362000.0 nM -
CHEMBL441241 Ki = 338000.0 nM -
CHEMBL46600 Ki = 438000.0 nM -
CHEMBL44487 Ki = 429000.0 nM -
CHEMBL45511 Ki = 159000.0 nM -
CHEMBL43727 Ki = 476000.0 nM -
CHEMBL45768 Ki = 260000.0 nM -