Assay Detail
Binding
CHEMBL878271
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In vitro binding affinity of compound for Dopamine transporter with [3H]- GBR-12935 as radioligand in corpus striatum tissue from rat forebrain
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Corpus striatum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
N-Phthalimidoalkyl derivatives of 2-carbomethoxy-3-(4-iodophenyl)tropane (-CIT): Brain monoamine transporter affinity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.53 | 9.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14391 | — | — | 1 | 9.02 |
| CHEMBL432029 | — | — | 1 | 8.62 |
| CHEMBL114837 | — | — | 1 | 8.62 |
| CHEMBL423692 | — | — | 1 | 8.53 |
| CHEMBL114547 | — | — | 1 | 8.37 |
| CHEMBL2112550 | — | — | 1 | 8.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14391 | — | Ki | = | 0.96 | nM | 9.02 |
| CHEMBL432029 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL114837 | — | Ki | = | 2.38 | nM | 8.62 |
| CHEMBL423692 | — | Ki | = | 2.98 | nM | 8.53 |
| CHEMBL114547 | — | Ki | = | 4.23 | nM | 8.37 |
| CHEMBL2112550 | — | Ki | = | 9.1 | nM | 8.04 |