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Assay Detail

CHEMBL878276

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Binding
Inhibitory activity against Endothelial nitric oxide synthase
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Nitric oxide synthase 3 (CHEMBL4803)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Inhibition of nitric oxide synthase by benzoxazolones
Shankaran K, Donnelly KL, Shah SK, Humes JL, Pacholok SG, Grant SK, Green BG, MacCoss M
Bioorg Med Chem Lett (1997) 7 : 2887 -2892
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 4.81 5.08

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL330433 1 5.08
CHEMBL1371 CHLORZOXAZONE 4.0 1 5.06
CHEMBL101439 1 4.97
CHEMBL99477 1 4.87
CHEMBL319405 1 4.83
CHEMBL95505 1 4.81
CHEMBL317806 1 4.80
CHEMBL95204 1 4.72
CHEMBL320444 1 4.69
CHEMBL319485 1 4.30
CHEMBL99703 1 -
CHEMBL320850 1 -
CHEMBL101266 1 -
CHEMBL97163 1 -
CHEMBL95524 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL330433 IC50 = 8400.0 nM 5.08
CHEMBL1371 CHLORZOXAZONE IC50 = 8700.0 nM 5.06
CHEMBL101439 IC50 = 10600.0 nM 4.97
CHEMBL99477 IC50 = 13600.0 nM 4.87
CHEMBL319405 IC50 = 14700.0 nM 4.83
CHEMBL95505 IC50 = 15500.0 nM 4.81
CHEMBL317806 IC50 = 15900.0 nM 4.80
CHEMBL95204 IC50 = 18900.0 nM 4.72
CHEMBL320444 IC50 = 20300.0 nM 4.69
CHEMBL319485 IC50 = 50000.0 nM 4.30
CHEMBL99703 IC50 > 50000.0 nM -
CHEMBL320850 IC50 > 50000.0 nM -
CHEMBL101266 IC50 > 50000.0 nM -
CHEMBL97163 IC50 > 50000.0 nM -
CHEMBL95524 IC50 > 50000.0 nM -