Compound Detail
CHEMBL1371
CHLORZOXAZONE 💊 Approved Drug
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL1371 |
| Name | CHLORZOXAZONE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | TZFWDZFKRBELIQ-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
4
Targets
4
Activities
1
Assay Types
3
PK Parameters
20
Publications
9
Known Names
1
Mechanisms
Molecular Properties
169.6
MW (Da)
1.77
ALogP
2
HBA
1
HBD
46.0
PSA (Ų)
0.65
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1958 |
| Availability | Prescription |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Intermediate conductance calcium-activated potassium channel protein 4 opener | OPENER | Intermediate conductance calcium-activated potassium channel protein 4 | ✓ | ✓ |
ATC Classification
M03BB03
chlorzoxazone
Level 1: MUSCULO-SKELETAL SYSTEM
Level 2: MUSCLE RELAXANTS
M03BB53
chlorzoxazone, combinations excl. psycholeptics
Level 1: MUSCULO-SKELETAL SYSTEM
Level 2: MUSCLE RELAXANTS
M03BB73
chlorzoxazone, combinations with psycholeptics
Level 1: MUSCULO-SKELETAL SYSTEM
Level 2: MUSCLE RELAXANTS
Activity Summary
IC50 4 meas. best 5.55
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Nitric oxide synthase 1 CHEMBL3048 | IC50 | 5.55 | 5.55 | 2794.0 | 1 |
| Nitric oxide synthase 3 CHEMBL4803 | IC50 | 5.06 | 5.06 | 8700.0 | 1 |
| Nitric oxide synthase, inducible CHEMBL4481 | IC50 | 4.85 | 4.85 | 14100.0 | 1 |
| Nitric oxide synthase 1 CHEMBL3568 | IC50 | 4.3 | 4.3 | 50000.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 10.96 | uL.min-1.(10^6cells)-1 | Homo sapiens |
| CL | 30.13 | mL.min-1.g-1 | Homo sapiens |
| F | 91.4 | % | Mus musculus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Nitric oxide synthase 1 | IC50 | = | 2794.0 | nM | 5.55 | DRUGMATRIX: Nitric Oxide Synthase, Neuronal (nNOS) radioligand binding (ligand: ... | - |
| Nitric oxide synthase 3 | IC50 | = | 8700.0 | nM | 5.06 | Inhibitory activity against Endothelial nitric oxide synthase | - |
| Nitric oxide synthase, inducible | IC50 | = | 14100.0 | nM | 4.85 | Inhibitory activity against Inducible nitric oxide synthase | - |
| Nitric oxide synthase 1 | IC50 | = | 50000.0 | nM | 4.3 | Inhibitory activity against Neuronal nitric oxide synthase | - |
Literature References
Data from ChEMBL 36 via Core Engine