Assay Detail
Functional
CHEMBL878324
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Leukotriene synthesis inhibition activity in the Human PMN assay
8
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
A new class of leukotriene biosynthesis inhibitors: The discovery of MK0591
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.89 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL31540 | — | — | 1 | 8.52 |
| CHEMBL16596 | QUIFLAPON | 2.0 | 1 | 8.52 |
| CHEMBL29097 | — | — | 1 | 8.52 |
| CHEMBL32842 | — | — | 3 | 8.30 |
| CHEMBL284066 | — | — | 1 | 7.52 |
| CHEMBL31896 | — | — | 1 | 6.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL31540 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL16596 | QUIFLAPON | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL29097 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL32842 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL32842 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL32842 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL284066 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL31896 | — | IC50 | = | 870.0 | nM | 6.06 |