Assay Detail
Binding
CHEMBL878424
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Inhibitory activity against rat brain Prolyl endopeptidase (PEP)
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Prolyl endopeptidase inhibitors1: N-acyl derivatives of L-thioproline-pyrrolidine
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.17 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL45594 | — | — | 1 | 7.96 |
| CHEMBL44744 | — | — | 1 | 7.77 |
| CHEMBL298028 | — | — | 1 | 7.70 |
| CHEMBL289651 | — | — | 1 | 7.52 |
| CHEMBL417354 | — | — | 1 | 7.47 |
| CHEMBL47990 | — | — | 1 | 7.43 |
| CHEMBL44745 | — | — | 1 | 7.43 |
| CHEMBL296645 | — | — | 1 | 7.42 |
| CHEMBL47565 | — | — | 1 | 7.42 |
| CHEMBL48005 | — | — | 1 | 7.38 |
| CHEMBL47927 | — | — | 1 | 7.34 |
| CHEMBL297237 | — | — | 1 | 7.14 |
| CHEMBL47926 | — | — | 1 | 7.10 |
| CHEMBL45684 | — | — | 1 | 6.98 |
| CHEMBL47932 | — | — | 1 | 6.78 |
| CHEMBL45668 | — | — | 1 | 6.68 |
| CHEMBL50765 | — | — | 1 | 6.67 |
| CHEMBL50764 | — | — | 1 | 6.04 |
| CHEMBL47936 | — | — | 1 | 5.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL45594 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL44744 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL298028 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL289651 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL417354 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL47990 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL44745 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL296645 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL47565 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL48005 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL47927 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL297237 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL47926 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL45684 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL47932 | — | IC50 | = | 167.0 | nM | 6.78 |
| CHEMBL45668 | — | IC50 | = | 207.0 | nM | 6.68 |
| CHEMBL50765 | — | IC50 | = | 216.0 | nM | 6.67 |
| CHEMBL50764 | — | IC50 | = | 904.0 | nM | 6.04 |
| CHEMBL47936 | — | IC50 | = | 1157.0 | nM | 5.94 |