Assay Detail
Binding
CHEMBL878465
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Inhibitory concentration against human Melanocortin 4 receptor (hMC4R)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Biological and conformational examination of stereochemical modifications using the template melanotropin peptide, Ac-Nle-c[Asp-His-Phe-Arg-Trp-Ala-Lys]-NH2, on human melanocortin receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.07 | 9.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL430239 | MELATONAN | — | 1 | 9.14 |
| CHEMBL2115441 | — | — | 1 | 9.05 |
| CHEMBL441738 | AFAMELANOTIDE | 4.0 | 1 | 8.94 |
| CHEMBL410217 | — | — | 1 | 8.69 |
| CHEMBL214332 | INTERMEDINE | 2.0 | 1 | 7.41 |
| CHEMBL3350396 | — | — | 1 | 7.15 |
| CHEMBL217584 | — | — | 1 | 7.11 |
| CHEMBL413260 | — | — | 1 | 7.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL430239 | MELATONAN | IC50 | = | 0.72 | nM | 9.14 |
| CHEMBL2115441 | — | IC50 | = | 0.89 | nM | 9.05 |
| CHEMBL441738 | AFAMELANOTIDE | IC50 | = | 1.16 | nM | 8.94 |
| CHEMBL410217 | — | IC50 | = | 2.03 | nM | 8.69 |
| CHEMBL214332 | INTERMEDINE | IC50 | = | 38.7 | nM | 7.41 |
| CHEMBL3350396 | — | IC50 | = | 71.5 | nM | 7.15 |
| CHEMBL217584 | — | IC50 | = | 77.8 | nM | 7.11 |
| CHEMBL413260 | — | IC50 | = | 91.0 | nM | 7.04 |