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Assay Detail

CHEMBL878650

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against Bovine Trypsin
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Serine protease 1 (CHEMBL3769)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Noncovalent thrombin inhibitors incorporating an imidazolylethynyl P1.
Lee K, Jung WH, Kang M, Lee SH.
Bioorg Med Chem Lett (2000) 10 : 2775 -2778
PubMed 11133089 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 10 7.56 7.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL94787 1 7.85
CHEMBL327189 1 7.75
CHEMBL7197 1 7.62
CHEMBL407631 1 7.62
CHEMBL96502 1 7.60
CHEMBL444548 1 7.52
CHEMBL319996 1 7.52
CHEMBL7962 1 7.48
CHEMBL330531 1 7.33
CHEMBL327601 1 7.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL94787 Ki = 14.0 nM 7.85
CHEMBL327189 Ki = 18.0 nM 7.75
CHEMBL7197 Ki = 24.0 nM 7.62
CHEMBL407631 Ki = 24.0 nM 7.62
CHEMBL96502 Ki = 25.0 nM 7.60
CHEMBL444548 Ki = 30.0 nM 7.52
CHEMBL319996 Ki = 30.0 nM 7.52
CHEMBL7962 Ki = 33.0 nM 7.48
CHEMBL330531 Ki = 47.0 nM 7.33
CHEMBL327601 Ki = 50.0 nM 7.30