Assay Detail
Binding
CHEMBL878705
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory activity against L-Hexonate Dehydrogenase (L-HDH) from rat kidney (RK)
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL2622) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Spiro[fluoreneisothiazolidin]one dioxides: new aldose reductase and L-hexonate dehydrogenase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.39 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269455 | IMIRESTAT | 2.0 | 1 | 8.30 |
| CHEMBL418832 | — | — | 1 | 8.05 |
| CHEMBL327139 | — | — | 1 | 7.57 |
| CHEMBL326920 | — | — | 1 | 6.98 |
| CHEMBL324907 | — | — | 1 | 6.82 |
| CHEMBL436 | TOLRESTAT | 4.0 | 1 | 6.02 |
| CHEMBL266497 | SORBINIL | 3.0 | 1 | 6.00 |
| CHEMBL325136 | — | — | 1 | 5.76 |
| CHEMBL322815 | — | — | 1 | 5.68 |
| CHEMBL7679 | PONALRESTAT | 2.0 | 1 | 5.62 |
| CHEMBL325596 | — | — | 1 | 5.46 |
| CHEMBL109865 | — | — | 1 | 5.43 |
| CHEMBL110661 | — | — | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269455 | IMIRESTAT | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL418832 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL327139 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL326920 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL324907 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL436 | TOLRESTAT | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL266497 | SORBINIL | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL325136 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL322815 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL7679 | PONALRESTAT | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL325596 | — | IC50 | = | 3510.0 | nM | 5.46 |
| CHEMBL109865 | — | IC50 | = | 3750.0 | nM | 5.43 |
| CHEMBL110661 | — | IC50 | = | 4500.0 | nM | 5.35 |