Assay Detail
Functional
CHEMBL878710
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Tested for Concentration required for the inhibition of ADP-induced aggregation of human platelets
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
A novel pyridazinone derivative as a nonprostanoid PGI2 agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.31 | 8.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94694 | — | — | 1 | 8.37 |
| CHEMBL430154 | — | — | 1 | 7.39 |
| CHEMBL94751 | — | — | 1 | 7.09 |
| CHEMBL318294 | — | — | 1 | 6.89 |
| CHEMBL268477 | AP-227 | — | 1 | 6.82 |
| CHEMBL318465 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94694 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL430154 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL94751 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL318294 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL268477 | AP-227 | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL318465 | — | IC50 | > | 10000.0 | nM | - |