Assay Detail
Binding
CHEMBL878759
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In vitro binding affinity by measuring the inhibition of bovine trypsin
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Design and synthesis of potent and highly selective thrombin inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 29 | 5.10 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20936 | BENZAMIDINE | — | 1 | 7.51 |
| CHEMBL341260 | — | — | 1 | 6.82 |
| CHEMBL216318 | — | — | 1 | 6.44 |
| CHEMBL126238 | — | — | 1 | 6.11 |
| CHEMBL409333 | — | — | 1 | 5.96 |
| CHEMBL325166 | NAPSAGATRAN ANHYDROUS | 2.0 | 1 | 5.72 |
| CHEMBL339094 | — | — | 1 | 5.51 |
| CHEMBL338669 | — | — | 1 | 5.42 |
| CHEMBL543183 | — | — | 1 | 5.27 |
| CHEMBL558215 | — | — | 1 | 5.12 |
| CHEMBL539559 | — | — | 1 | 5.07 |
| CHEMBL555314 | — | — | 1 | 4.92 |
| CHEMBL559194 | — | — | 1 | 4.77 |
| CHEMBL128980 | — | — | 1 | 4.70 |
| CHEMBL558610 | — | — | 1 | 4.70 |
| CHEMBL543893 | — | — | 1 | 4.64 |
| CHEMBL544830 | — | — | 1 | 4.58 |
| CHEMBL542951 | — | — | 1 | 4.57 |
| CHEMBL553963 | — | — | 1 | 4.57 |
| CHEMBL539557 | — | — | 1 | 4.55 |
| CHEMBL543419 | — | — | 1 | 4.52 |
| CHEMBL544130 | — | — | 1 | 4.51 |
| CHEMBL552997 | — | — | 1 | 4.50 |
| CHEMBL544356 | — | — | 1 | 4.48 |
| CHEMBL539047 | — | — | 1 | 4.38 |
| CHEMBL539815 | — | — | 1 | 4.32 |
| CHEMBL544131 | — | — | 1 | 4.12 |
| CHEMBL340184 | — | — | 1 | - |
| CHEMBL540073 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20936 | BENZAMIDINE | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL341260 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL216318 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL126238 | — | Ki | = | 780.0 | nM | 6.11 |
| CHEMBL409333 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL325166 | NAPSAGATRAN ANHYDROUS | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL339094 | — | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL338669 | — | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL543183 | — | Ki | = | 5400.0 | nM | 5.27 |
| CHEMBL558215 | — | Ki | = | 7500.0 | nM | 5.12 |
| CHEMBL539559 | — | Ki | = | 8600.0 | nM | 5.07 |
| CHEMBL555314 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL559194 | — | Ki | = | 17000.0 | nM | 4.77 |
| CHEMBL128980 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL558610 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL543893 | — | Ki | = | 23000.0 | nM | 4.64 |
| CHEMBL544830 | — | Ki | = | 26000.0 | nM | 4.58 |
| CHEMBL542951 | — | Ki | = | 27000.0 | nM | 4.57 |
| CHEMBL553963 | — | Ki | = | 27000.0 | nM | 4.57 |
| CHEMBL539557 | — | Ki | = | 28000.0 | nM | 4.55 |
| CHEMBL543419 | — | Ki | = | 30000.0 | nM | 4.52 |
| CHEMBL544130 | — | Ki | = | 31000.0 | nM | 4.51 |
| CHEMBL552997 | — | Ki | = | 32000.0 | nM | 4.50 |
| CHEMBL544356 | — | Ki | = | 33000.0 | nM | 4.48 |
| CHEMBL539047 | — | Ki | = | 42000.0 | nM | 4.38 |
| CHEMBL539815 | — | Ki | = | 48000.0 | nM | 4.32 |
| CHEMBL544131 | — | Ki | = | 75000.0 | nM | 4.12 |
| CHEMBL340184 | — | Ki | = | 130000.0 | nM | - |
| CHEMBL540073 | — | Ki | = | 130000.0 | nM | - |