Assay Detail
Functional
CHEMBL878772
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for production of leukotriene B4 in Ca+2 -ionophore -activated human polymorphonuclear (HPMN) leukocytes.
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Substituted (pyridylmethoxy)naphthalenes as potent and orally active 5-lipoxygenase inhibitors; synthesis, biological profile, and pharmacokinetics of L-739,010.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 8.20 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99217 | — | — | 1 | 9.22 |
| CHEMBL278293 | — | — | 1 | 8.80 |
| CHEMBL99469 | — | — | 1 | 8.70 |
| CHEMBL16596 | QUIFLAPON | 2.0 | 1 | 8.52 |
| CHEMBL97380 | — | — | 1 | 8.52 |
| CHEMBL95470 | — | — | 1 | 8.51 |
| CHEMBL99942 | — | — | 1 | 8.46 |
| CHEMBL97923 | — | — | 1 | 8.30 |
| CHEMBL418775 | — | — | 1 | 8.05 |
| CHEMBL316641 | — | — | 1 | 8.00 |
| CHEMBL421391 | — | — | 1 | 7.36 |
| CHEMBL93 | ZILEUTON | 4.0 | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99217 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL278293 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL99469 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL16596 | QUIFLAPON | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL97380 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL95470 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL99942 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL97923 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL418775 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL316641 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL421391 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL93 | ZILEUTON | IC50 | = | 1100.0 | nM | 5.96 |