Assay Detail
Binding
CHEMBL878778
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IC50 value against Prostaglandin G/H synthase 1 of human platelet rich plasma
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Plasma |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 2. 1,3,4- and 1,2,4-thiadiazole series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 5.81 | 8.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 8.09 |
| CHEMBL12532 | — | — | 1 | 6.75 |
| CHEMBL16881 | — | — | 1 | 6.70 |
| CHEMBL275188 | — | — | 1 | 6.70 |
| CHEMBL279755 | — | — | 1 | 6.52 |
| CHEMBL279308 | — | — | 1 | 6.37 |
| CHEMBL417073 | — | — | 1 | 6.28 |
| CHEMBL17218 | — | — | 1 | 6.17 |
| CHEMBL280326 | — | — | 1 | 6.11 |
| CHEMBL16733 | — | — | 1 | 5.92 |
| CHEMBL16981 | — | — | 1 | 5.92 |
| CHEMBL17229 | — | — | 1 | 5.92 |
| CHEMBL274457 | — | — | 1 | 5.92 |
| CHEMBL17104 | — | — | 1 | 5.77 |
| CHEMBL16819 | — | — | 1 | 5.72 |
| CHEMBL276526 | — | — | 1 | 5.72 |
| CHEMBL16878 | — | — | 1 | 5.55 |
| CHEMBL16826 | — | — | 1 | 5.55 |
| CHEMBL279801 | — | — | 1 | 5.51 |
| CHEMBL16977 | — | — | 1 | 5.50 |
| CHEMBL16891 | — | — | 1 | 5.50 |
| CHEMBL7162 | NS-398 | — | 1 | 5.48 |
| CHEMBL16912 | — | — | 1 | 5.44 |
| CHEMBL279387 | — | — | 1 | 5.44 |
| CHEMBL17307 | — | — | 1 | 5.44 |
| CHEMBL275838 | — | — | 1 | 5.39 |
| CHEMBL16827 | — | — | 1 | 5.39 |
| CHEMBL16854 | — | — | 1 | 5.35 |
| CHEMBL16814 | — | — | 1 | 5.24 |
| CHEMBL16698 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL12532 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL16881 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL275188 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL279755 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL279308 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL417073 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL17218 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL280326 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL274457 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL17229 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL16981 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL16733 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL17104 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL276526 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL16819 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL16878 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL16826 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL279801 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL16977 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL16891 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL7162 | NS-398 | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL16912 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL17307 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL279387 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL275838 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL16827 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL16854 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL16814 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL16698 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL16674 | — | IC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL16843 | — | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL278040 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL276062 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL279336 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL274990 | SC-58125 | IC50 | > | 20000.0 | nM | - |
| CHEMBL16522 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL16753 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL16647 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL416165 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL16828 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL16659 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL276916 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL274271 | — | IC50 | > | 20000.0 | nM | - |