Assay Detail
Functional
CHEMBL878982
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Inhibition of p38-related IL1-beta release by whole blood cells at 10 e-4 to 10 e-8 M
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.63 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10 | SB-203580 | — | 1 | 6.46 |
| CHEMBL111364 | — | — | 1 | 6.00 |
| CHEMBL109352 | — | — | 1 | 5.97 |
| CHEMBL113419 | — | — | 1 | 5.92 |
| CHEMBL111053 | — | — | 1 | 5.70 |
| CHEMBL323734 | — | — | 1 | 5.67 |
| CHEMBL111210 | — | — | 1 | 5.66 |
| CHEMBL320130 | — | — | 1 | 5.57 |
| CHEMBL111456 | — | — | 1 | 5.56 |
| CHEMBL324977 | — | — | 1 | 5.39 |
| CHEMBL432798 | — | — | 1 | 4.97 |
| CHEMBL323479 | — | — | 1 | 4.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10 | SB-203580 | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL111364 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL109352 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL113419 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL111053 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL323734 | — | IC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL111210 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL320130 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL111456 | — | IC50 | = | 2780.0 | nM | 5.56 |
| CHEMBL324977 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL432798 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL323479 | — | IC50 | = | 18500.0 | nM | 4.73 |