Assay Detail
Functional
CHEMBL879027
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro cytotoxicity against GCT / cisR cell lines
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | GCT/cisR |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and cytotoxicity of potential tumor-inhibitory analogues of trimelamol (2,4,6-tris[(hydroxymethyl)methylamino]-1,3,5-triazine) having electron-withdrawing groups in place of methyl.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.49 | 4.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL422976 | — | — | 1 | 4.62 |
| CHEMBL133987 | TRIMELAMOL | — | 1 | 4.51 |
| CHEMBL135064 | — | — | 1 | 4.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL422976 | — | IC50 | = | 23700.0 | nM | 4.62 |
| CHEMBL133987 | TRIMELAMOL | IC50 | = | 30900.0 | nM | 4.51 |
| CHEMBL135064 | — | IC50 | = | 47300.0 | nM | 4.33 |