Assay Detail
Functional
CHEMBL879143
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Transcriptional activation in CV-1 cells expressing retinoid X receptor RXR beta
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CV-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of potent conformationally restricted retinoid X receptor ligands
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.02 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL92284 | — | — | 1 | 7.89 |
| CHEMBL93518 | — | — | 1 | 7.72 |
| CHEMBL1023 | BEXAROTENE | 4.0 | 1 | 7.62 |
| CHEMBL93848 | — | — | 1 | 6.90 |
| CHEMBL96184 | — | — | 1 | 6.31 |
| CHEMBL92394 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL92284 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL93518 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1023 | BEXAROTENE | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL93848 | — | EC50 | = | 127.0 | nM | 6.90 |
| CHEMBL96184 | — | EC50 | = | 486.0 | nM | 6.31 |
| CHEMBL92394 | — | EC50 | = | 2000.0 | nM | 5.70 |