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Compound Detail

CHEMBL92394

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CC(/C=C/C1(c2cc3c(cc2C)C(C)(C)CCC3(C)C)CCCC1)=C\C(=O)O

Basic Information

ChEMBL ID CHEMBL92394
Phase Preclinical
Structure Type MOL
InChI Key NSUMJVKYPHTODI-FPIZNTTDSA-N
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

380.6
MW (Da)
6.74
ALogP
1
HBA
1
HBD
37.3
PSA (Ų)
0.46
QED
1
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C26H36O2
MW 380.57
Aromatic Rings 1
Heavy Atoms 28
NP-Likeness 0.93

Activity Summary

EC50 5 meas. best 6.09

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Retinoic acid receptor beta
CHEMBL2008
EC50 6.09 6.09 809.0 1
Retinoic acid receptor gamma
CHEMBL2003
EC50 5.75 5.75 1779.0 1
Retinoic acid receptor RXR-beta
CHEMBL1870
EC50 5.7 5.7 2000.0 1
Retinoic acid receptor RXR-alpha
CHEMBL2061
EC50 5.6 5.6 2520.0 1
Retinoic acid receptor RXR-gamma
CHEMBL2004
EC50 5.57 5.57 2714.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.1016/S0960-894X(97)10079-8 Retinoic acid receptor alpha 3
- 10.1016/S0960-894X(97)10079-8 Retinoic acid receptor beta 3
- 10.1016/S0960-894X(97)10079-8 Retinoic acid receptor gamma 3
- 10.1016/S0960-894X(97)10079-8 Retinoic acid receptor RXR-alpha 3
- 10.1016/S0960-894X(97)10079-8 Retinoic acid receptor RXR-beta 3
- 10.1016/S0960-894X(97)10079-8 Retinoic acid receptor RXR-gamma 3

Data from ChEMBL 36 via Core Engine