Assay Detail
Binding
CHEMBL879268
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In vitro binding affinity to the Muscarinic acetylcholine receptor by displacing [3H]OXO-M from the rat brain tissues
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Annulated heterocyclic bioisosteres of norarecoline. Synthesis and molecular pharmacology at five recombinant human muscarinic acetylcholine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.39 | 9.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL69306 | — | — | 1 | 9.12 |
| CHEMBL69305 | — | — | 1 | 8.47 |
| CHEMBL304142 | — | — | 1 | 8.00 |
| CHEMBL305264 | — | — | 1 | 7.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL69306 | — | IC50 | = | 0.75 | nM | 9.12 |
| CHEMBL69305 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL304142 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL305264 | — | IC50 | = | 11.0 | nM | 7.96 |