Assay Detail
Functional
CHEMBL879334
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Inhibition of 5-HT reuptake in rat cerebrospinal fluid (CSF) was measured
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Cerebrospinal fluid |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel tryptophan dioxygenase inhibitors and combined tryptophan dioxygenase/5-HT reuptake inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.94 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL435072 | — | — | 1 | 6.05 |
| CHEMBL166509 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL435072 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL166509 | — | IC50 | = | 1500.0 | nM | 5.82 |