Assay Detail
Functional
CHEMBL879350
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The compound was tested for inhibition of Cholesterol synthesis from [14C]- Acetate in hepatocytes of rats.
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Hepatocyte |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Phosphorus-containing inhibitors of HMG-CoA reductase. 2. Synthesis and biological activities of a series of substituted pyridines containing a hydroxyphosphinyl moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.92 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL690 | PRAVASTATIN SODIUM | 4.0 | 1 | 7.00 |
| CHEMBL418776 | — | — | 1 | 6.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL690 | PRAVASTATIN SODIUM | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL418776 | — | IC50 | = | 146.0 | nM | 6.84 |