Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL879362

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Tested in vitro for the inhibition of iron-dependent lipid peroxidation against rat brain homogenates, by malondialdehyde (MDA) formation assay
ChEMBL ↗
55
Total Activities
54
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Tissue Brain
Confidence 1 — Organism
Curated By Expert

Target

Rattus norvegicus (CHEMBL376) ↗
Type ORGANISM
Organism Rattus norvegicus

Publication

2-(Aminomethyl)chromans that inhibit iron-dependent lipid peroxidation and protect against central nervous system trauma and ischemia.
Jacobsen EJ, VanDoornik FJ, Ayer DE, Belonga KL, Braughler JM, Hall ED, Houser DJ.
J Med Chem (1992) 35 : 4464 -4472
PubMed 1447746 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 55 5.60 6.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1203330 — — 1 6.70
CHEMBL140660 — — 1 6.70
CHEMBL140882 — — 1 6.70
CHEMBL343592 — — 1 6.30
CHEMBL2092979 — — 1 6.22
CHEMBL142008 — — 1 6.16
CHEMBL343985 — — 1 6.16
CHEMBL336459 — — 1 6.10
CHEMBL343762 — — 1 6.10
CHEMBL335820 — — 1 6.05
CHEMBL1202008 — — 1 6.05
CHEMBL137908 — — 1 6.00
CHEMBL1203321 — — 1 6.00
CHEMBL1202007 — — 1 6.00
CHEMBL1203323 — — 1 6.00
CHEMBL1203329 — — 1 6.00
CHEMBL1203328 — — 1 6.00
CHEMBL1203327 — — 1 6.00
CHEMBL1203322 — — 1 6.00
CHEMBL141155 — — 1 6.00
CHEMBL140699 — — 1 6.00
CHEMBL1203320 — — 1 6.00
CHEMBL275785 — — 1 6.00
CHEMBL1203324 — — 2 5.96
CHEMBL1202005 — — 1 5.89
CHEMBL141734 — — 1 5.89
CHEMBL423005 — — 1 5.89
CHEMBL138926 — — 1 5.85
CHEMBL138360 — — 1 5.82
CHEMBL139905 — — 1 5.77

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1203330 — IC50 = 200.0 nM 6.70
CHEMBL140882 — IC50 = 200.0 nM 6.70
CHEMBL140660 — IC50 = 200.0 nM 6.70
CHEMBL343592 — IC50 = 500.0 nM 6.30
CHEMBL2092979 — IC50 = 600.0 nM 6.22
CHEMBL142008 — IC50 = 700.0 nM 6.16
CHEMBL343985 — IC50 = 700.0 nM 6.16
CHEMBL343762 — IC50 = 800.0 nM 6.10
CHEMBL336459 — IC50 = 800.0 nM 6.10
CHEMBL335820 — IC50 = 900.0 nM 6.05
CHEMBL1202008 — IC50 = 900.0 nM 6.05
CHEMBL141155 — IC50 = 1000.0 nM 6.00
CHEMBL1203321 — IC50 = 1000.0 nM 6.00
CHEMBL1202007 — IC50 = 1000.0 nM 6.00
CHEMBL1203323 — IC50 = 1000.0 nM 6.00
CHEMBL1203329 — IC50 = 1000.0 nM 6.00
CHEMBL1203328 — IC50 = 1000.0 nM 6.00
CHEMBL1203327 — IC50 = 1000.0 nM 6.00
CHEMBL1203322 — IC50 = 1000.0 nM 6.00
CHEMBL137908 — IC50 = 1000.0 nM 6.00
CHEMBL140699 — IC50 = 1000.0 nM 6.00
CHEMBL1203320 — IC50 = 1000.0 nM 6.00
CHEMBL275785 — IC50 = 1000.0 nM 6.00
CHEMBL1203324 — IC50 = 1100.0 nM 5.96
CHEMBL423005 — IC50 = 1300.0 nM 5.89
CHEMBL141734 — IC50 = 1300.0 nM 5.89
CHEMBL1202005 — IC50 = 1300.0 nM 5.89
CHEMBL138926 — IC50 = 1400.0 nM 5.85
CHEMBL138360 — IC50 = 1500.0 nM 5.82
CHEMBL1203324 — IC50 = 1500.0 nM 5.82
CHEMBL139905 — IC50 = 1700.0 nM 5.77
CHEMBL139681 — IC50 = 1800.0 nM 5.75
CHEMBL137862 — IC50 = 2300.0 nM 5.64
CHEMBL344157 — IC50 = 3000.0 nM 5.52
CHEMBL138529 — IC50 = 4100.0 nM 5.39
CHEMBL336717 — IC50 = 5400.0 nM 5.27
CHEMBL341804 — IC50 = 5500.0 nM 5.26
CHEMBL141752 — IC50 = 8700.0 nM 5.06
CHEMBL422467 — IC50 = 10000.0 nM 5.00
CHEMBL138483 — IC50 = 10000.0 nM 5.00
CHEMBL1202006 — IC50 = 11000.0 nM 4.96
CHEMBL343552 — IC50 = 11000.0 nM 4.96
CHEMBL141561 — IC50 = 12000.0 nM 4.92
CHEMBL138578 — IC50 = 15000.0 nM 4.82
CHEMBL1203331 — IC50 = 16000.0 nM 4.80
CHEMBL139575 — IC50 = 17000.0 nM 4.77
CHEMBL1630578 TIRILAZAD IC50 = 18000.0 nM 4.75
CHEMBL1202011 — IC50 = 23000.0 nM 4.64
CHEMBL138403 — IC50 = 23000.0 nM 4.64
CHEMBL47 ALPHA-TOCOPHEROL IC50 = 28000.0 nM 4.55