Assay Detail
Functional
CHEMBL879468
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGFR overexpressing HN5 (Head and neck) tumor cell proliferation
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery and biological evaluation of potent dual ErbB-2/EGFR tyrosine kinase inhibitors: 6-thiazolylquinazolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.25 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL155761 | — | — | 1 | 7.10 |
| CHEMBL160303 | — | — | 1 | 6.96 |
| CHEMBL160846 | — | — | 1 | 6.64 |
| CHEMBL157084 | — | — | 1 | 6.24 |
| CHEMBL422347 | — | — | 1 | 5.80 |
| CHEMBL269620 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL155761 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL160303 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL160846 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL157084 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL422347 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL269620 | — | IC50 | = | 18000.0 | nM | 4.75 |