Assay Detail
Functional
CHEMBL879560
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for efficacy in a challenge intraurethral pressure (IUP) model using aged anesthetized dogs
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Canis lupus familiaris |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and pharmacological characterization of 3-[2-((3aR,9bR)-cis-6-methoxy-2,3,3a,4,5,9b-hexahydro-1H-benz[e] isoindol-2-yl)ethyl]pyrido-[3',4':4,5]thieno[3,2-d]pyrimidine-2,4 (1H,3H)-dione (A-131701): a uroselective alpha 1A adrenoceptor antagonist for the symptomatic treatment of benign prostatic hyperplasia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 8.02 | 8.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL836 | TAMSULOSIN | 4.0 | 1 | 8.87 |
| CHEMBL40650 | — | — | 1 | 8.17 |
| CHEMBL611 | TERAZOSIN | 4.0 | 1 | 7.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL836 | TAMSULOSIN | Kd | = | 1.349 | nM | 8.87 |
| CHEMBL40650 | — | Kd | = | 6.761 | nM | 8.17 |
| CHEMBL611 | TERAZOSIN | Kd | = | 95.5 | nM | 7.02 |