Assay Detail
Binding
CHEMBL879565
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatum
14
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
3-amino-3,4-dihydro-2H-1-benzopyran derivatives as 5-HT1A receptor ligands and potential anxiolytic agents. 2. Synthesis and quantitative structure-activity relationship studies of spiro[pyrrolidine- and piperidine-2,3'(2'H)-benzopyrans]
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.47 | 4.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8412 | IPSAPIRONE | 2.0 | 1 | 4.92 |
| CHEMBL11592 | — | — | 3 | 4.70 |
| CHEMBL11265 | — | — | 2 | 4.65 |
| CHEMBL422283 | — | — | 1 | 4.63 |
| CHEMBL137486 | — | — | 1 | 4.42 |
| CHEMBL334498 | — | — | 1 | 4.42 |
| CHEMBL137478 | — | — | 1 | 4.00 |
| CHEMBL283606 | — | — | 1 | 4.00 |
| CHEMBL135489 | — | — | 1 | - |
| CHEMBL49 | BUSPIRONE | 4.0 | 1 | - |
| CHEMBL422453 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8412 | IPSAPIRONE | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL11592 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL11265 | — | IC50 | = | 22400.0 | nM | 4.65 |
| CHEMBL422283 | — | IC50 | = | 23400.0 | nM | 4.63 |
| CHEMBL11265 | — | IC50 | = | 23300.0 | nM | 4.63 |
| CHEMBL137486 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL334498 | — | IC50 | = | 38300.0 | nM | 4.42 |
| CHEMBL11592 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL11592 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL137478 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL283606 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL135489 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL49 | BUSPIRONE | IC50 | = | 270000.0 | nM | - |
| CHEMBL422453 | — | IC50 | = | 120000.0 | nM | - |