Assay Detail
Binding
CHEMBL879567
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Binding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligand
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Cyanoindole derivatives as highly selective dopamine D(4) receptor partial agonists: solid-phase synthesis, binding assays, and functional experiments.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.40 | 6.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL344602 | — | — | 1 | 6.06 |
| CHEMBL140258 | — | — | 1 | 5.72 |
| CHEMBL343880 | — | — | 1 | 5.28 |
| CHEMBL140594 | — | — | 1 | 5.28 |
| CHEMBL143761 | — | — | 1 | 5.07 |
| CHEMBL140006 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL344602 | — | Ki | = | 880.0 | nM | 6.06 |
| CHEMBL140258 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL343880 | — | Ki | = | 5300.0 | nM | 5.28 |
| CHEMBL140594 | — | Ki | = | 5300.0 | nM | 5.28 |
| CHEMBL143761 | — | Ki | = | 8600.0 | nM | 5.07 |
| CHEMBL140006 | — | Ki | = | 11000.0 | nM | 4.96 |