Assay Detail
Binding
CHEMBL879670
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Concentration required for in vitro motilin receptor binding, expressed as negative logarithm of IC50
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Potent, acid-stable and orally active macrolide-type motilin receptor agonists, GM-611 and the derivatives
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.97 | 8.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL26966 | — | — | 1 | 8.50 |
| CHEMBL300004 | — | — | 1 | 8.47 |
| CHEMBL265495 | — | — | 1 | 8.42 |
| CHEMBL27424 | — | — | 1 | 8.22 |
| CHEMBL27419 | — | — | 1 | 8.04 |
| CHEMBL406517 | — | — | 1 | 7.36 |
| CHEMBL281952 | — | — | 1 | 6.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL26966 | — | IC50 | = | 3.162 | nM | 8.50 |
| CHEMBL300004 | — | IC50 | = | 3.388 | nM | 8.47 |
| CHEMBL265495 | — | IC50 | = | 3.802 | nM | 8.42 |
| CHEMBL27424 | — | IC50 | = | 6.026 | nM | 8.22 |
| CHEMBL27419 | — | IC50 | = | 9.12 | nM | 8.04 |
| CHEMBL406517 | — | IC50 | = | 43.65 | nM | 7.36 |
| CHEMBL281952 | — | IC50 | = | 154.88 | nM | 6.81 |