Assay Detail
Functional
CHEMBL879738
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Effective concentration of compound required to reduce the cytopathic effect of HIV-1 IIIB in MT-4 cells by 50%
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Identification of optimal anion spacing for anti-HIV activity in a series of cosalane tetracarboxylates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 5.35 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3138345 | — | — | 1 | 5.77 |
| CHEMBL3138370 | — | — | 1 | 5.66 |
| CHEMBL3138187 | — | — | 1 | 5.52 |
| CHEMBL3138119 | — | — | 1 | 5.36 |
| CHEMBL3138438 | — | — | 1 | 4.92 |
| CHEMBL3138133 | — | — | 1 | 4.84 |
| CHEMBL3138376 | — | — | 1 | - |
| CHEMBL3138383 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3138345 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL3138370 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL3138187 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3138119 | — | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL3138438 | — | EC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL3138133 | — | EC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL3138376 | — | EC50 | > | 37000.0 | nM | - |
| CHEMBL3138383 | — | EC50 | > | 80000.0 | nM | - |