Assay Detail
Binding
CHEMBL879860
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]RTI-55 from dopamine transporter of rat brain membranes
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis of 3 beta-aryl-8-azabicyclo[3.2.1]octanes with high binding affinities and selectivities for the serotonin transporter site.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.59 | 9.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL418190 | — | — | 1 | 9.92 |
| CHEMBL314361 | — | — | 1 | 9.05 |
| CHEMBL85492 | — | — | 1 | 8.82 |
| CHEMBL87983 | — | — | 1 | 8.33 |
| CHEMBL82807 | — | — | 1 | 8.14 |
| CHEMBL23142 | — | — | 1 | 8.09 |
| CHEMBL85877 | — | — | 1 | 7.80 |
| CHEMBL36720 | — | — | 1 | 7.44 |
| CHEMBL87678 | — | — | 1 | 6.72 |
| CHEMBL314919 | — | — | 1 | 6.57 |
| CHEMBL87739 | — | — | 1 | 6.50 |
| CHEMBL278122 | — | — | 1 | 6.36 |
| CHEMBL84899 | — | — | 1 | 6.31 |
| CHEMBL85256 | — | — | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL418190 | — | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL314361 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL85492 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL87983 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL82807 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL23142 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL85877 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL36720 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL87678 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL314919 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL87739 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL278122 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL84899 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL85256 | — | IC50 | = | 540.0 | nM | 6.27 |