Assay Detail
Binding
CHEMBL879870
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Binding towards Dopamine receptor D2 expressed in CHO-K1 cells using [3H]U-86170
9
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Substituted 3-phenylpiperidines: new centrally acting dopamine autoreceptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.44 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 9.15 |
| CHEMBL276500 | — | — | 2 | 8.07 |
| CHEMBL278751 | — | — | 1 | 7.89 |
| CHEMBL90359 | — | — | 1 | 7.40 |
| CHEMBL107492 | — | — | 2 | 6.92 |
| CHEMBL27441 | — | — | 1 | 6.84 |
| CHEMBL110821 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL276500 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL278751 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL276500 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL90359 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL107492 | — | Ki | = | 119.0 | nM | 6.92 |
| CHEMBL27441 | — | Ki | = | 145.0 | nM | 6.84 |
| CHEMBL107492 | — | Ki | = | 1724.0 | nM | 5.76 |
| CHEMBL110821 | — | Ki | > | 2000.0 | nM | - |