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Assay Detail

CHEMBL880153

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro inhibition of human cytomegalovirus in HFF cells by plaque reduction assay.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HFF
Confidence 1 — Organism
Curated By Expert

Target

HFF (CHEMBL614071)
Type CELL-LINE
Organism Homo sapiens

Publication

Design, synthesis and activity against human cytomegalovirus of non-phosphorylatable analogs of toyocamycin, sangivamycin and thiosangivamycin
Renau TE, Ludwig MS, Drach JC, Townsend LB
Bioorg Med Chem Lett (1992) 2 : 1755 -1760
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 5.73 7.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL298790 1 7.52
CHEMBL48549 1 6.72
CHEMBL299814 1 5.92
CHEMBL51847 1 5.92
CHEMBL48547 1 5.68
CHEMBL300485 1 5.21
CHEMBL182 GANCICLOVIR 4.0 1 5.08
CHEMBL30286 1 5.06
CHEMBL50996 1 4.44
CHEMBL297893 1 -
CHEMBL33236 1 -
CHEMBL52038 1 -
CHEMBL300084 1 -
CHEMBL48444 1 -
CHEMBL34163 1 -
CHEMBL297745 1 -
CHEMBL51484 1 -
CHEMBL50879 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL298790 IC50 = 30.0 nM 7.52
CHEMBL48549 IC50 = 190.0 nM 6.72
CHEMBL299814 IC50 = 1200.0 nM 5.92
CHEMBL51847 IC50 = 1200.0 nM 5.92
CHEMBL48547 IC50 = 2100.0 nM 5.68
CHEMBL300485 IC50 = 6200.0 nM 5.21
CHEMBL182 GANCICLOVIR IC50 = 8400.0 nM 5.08
CHEMBL30286 IC50 = 8800.0 nM 5.06
CHEMBL50996 IC50 = 36000.0 nM 4.44
CHEMBL297893 IC50 > 100000.0 nM -
CHEMBL33236 IC50 > 100000.0 nM -
CHEMBL52038 IC50 > 100000.0 nM -
CHEMBL300084 IC50 > 100000.0 nM -
CHEMBL48444 IC50 > 100000.0 nM -
CHEMBL34163 IC50 > 100000.0 nM -
CHEMBL297745 IC50 > 100000.0 nM -
CHEMBL51484 IC50 > 100000.0 nM -
CHEMBL50879 IC50 > 100000.0 nM -