Assay Detail
Functional
CHEMBL880202
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Protection of MT-4 cells against the cytopathic effect of HIV-1 (4 days)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antiviral activity of 8-aza analogs of chiral [2-(phosphonomethoxy) propyl]guanines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 5.36 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.00 |
| CHEMBL223737 | GS-438 | -1.0 | 1 | 6.72 |
| CHEMBL91794 | — | — | 1 | 5.35 |
| CHEMBL341005 | — | — | 1 | 4.92 |
| CHEMBL338348 | — | — | 1 | 4.82 |
| CHEMBL92761 | — | — | 1 | 4.72 |
| CHEMBL132576 | — | — | 1 | 4.28 |
| CHEMBL128087 | — | — | 1 | 4.03 |
| CHEMBL132120 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL223737 | GS-438 | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL91794 | — | EC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL341005 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL338348 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL92761 | — | EC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL132576 | — | EC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL128087 | — | EC50 | = | 93000.0 | nM | 4.03 |
| CHEMBL132120 | — | EC50 | > | 400000.0 | nM | - |