Assay Detail
Functional
CHEMBL880211
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of anti-CD3, anti-CD28 induced PBL T-cell proliferation
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Molecular design, synthesis, and structure-Activity relationships leading to the potent and selective p56(lck) inhibitor BMS-243117.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.77 | 6.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308432 | — | — | 1 | 6.02 |
| CHEMBL67237 | — | — | 1 | 5.96 |
| CHEMBL68261 | — | — | 1 | 5.84 |
| CHEMBL68882 | — | — | 1 | 5.80 |
| CHEMBL68871 | — | — | 1 | 5.55 |
| CHEMBL309103 | — | — | 1 | 5.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308432 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL67237 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL68261 | — | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL68882 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL68871 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL309103 | — | IC50 | = | 3530.0 | nM | 5.45 |