Assay Detail
Binding
CHEMBL880234
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Inhibitory activity against p38 at a concentration of 1.0 uM
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
The neuroprotective action of JNK3 inhibitors based on the 6,7-dihydro-5H-pyrrolo[1,2-a]imidazole scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.08 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL198756 | — | — | 1 | 7.55 |
| CHEMBL383799 | — | — | 1 | 7.51 |
| CHEMBL383348 | — | — | 1 | 7.27 |
| CHEMBL198427 | — | — | 1 | 6.94 |
| CHEMBL198261 | — | — | 1 | 6.66 |
| CHEMBL372082 | — | — | 1 | 6.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL198756 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL383799 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL383348 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL198427 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL198261 | — | IC50 | = | 217.0 | nM | 6.66 |
| CHEMBL372082 | — | IC50 | = | 295.0 | nM | 6.53 |