Assay Detail
Binding
CHEMBL880246
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against recombinant human cytochrome P450 17A1 using progesterone as substrate
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Steroid 17-alpha-hydroxylase/17,20 lyase (CHEMBL3522) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Heteroaryl-substituted naphthalenes and structurally modified derivatives: selective inhibitors of CYP11B2 for the treatment of congestive heart failure and myocardial fibrosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.64 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL371430 | — | — | 1 | 7.57 |
| CHEMBL381014 | — | — | 1 | 6.63 |
| CHEMBL362968 | — | — | 1 | 6.18 |
| CHEMBL196796 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL371430 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL381014 | — | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL362968 | — | IC50 | = | 667.0 | nM | 6.18 |
| CHEMBL196796 | — | IC50 | = | 686.0 | nM | 6.16 |