Assay Detail

CHEMBL880253

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

In vitro inhibitory concentration against IGF-1R Sal kinase with ATP concentration at 1/2Km

ChEMBL ↗

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Target

Insulin-like growth factor 1 receptor (CHEMBL1957) ↗

Open DB target context

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Insulin-like growth factor 1 receptor (CHEMBL1957) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Insulin-like growth factor 1 receptor

CHEMBL1957

Anchored from Assay target.

Protein identity Insulin-like growth factor 1 receptor

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Expert

Target

Insulin-like growth factor 1 receptor (CHEMBL1957) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitumor activity.

Wittman M, Carboni J, Attar R, Balasubramanian B, Balimane P, Brassil P, Beaulieu F, Chang C, Clarke W, Dell J, Eummer J, Frennesson D, Gottardis M, Greer A, Hansel S, Hurlburt W, Jacobson B, Krishnananthan S, Lee FY, Li A, Lin TA, Liu P, Ouellet C, Sang X, Saulnier MG, Stoffan K, Sun Y, Velaparthi U, Wong H, Yang Z, Zimmermann K, Zoeckler M, Vyas D.
J Med Chem (2005) 48 : 5639 -5643
PubMed 16134929 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.96	6.96

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL401930	—	—	1	6.96

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL401930	—	IC50	=	110.0	nM	6.96