Assay Detail
Binding
CHEMBL880442
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In vitro inhibition of human coagulation factor Xa after incubation for 10 min at 25 degree C
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of the novel antithrombotic agent 5-chloro-N-({(5S)-2-oxo-3- [4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene- 2-carboxamide (BAY 59-7939): an oral, direct factor Xa inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.43 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL383361 | — | — | 1 | 9.40 |
| CHEMBL198362 | RIVAROXABAN | 4.0 | 1 | 9.15 |
| CHEMBL194186 | — | — | 1 | 9.00 |
| CHEMBL364284 | — | — | 1 | 8.85 |
| CHEMBL196539 | — | — | 1 | 8.60 |
| CHEMBL197377 | — | — | 1 | 8.40 |
| CHEMBL370614 | — | — | 1 | 8.38 |
| CHEMBL194193 | — | — | 1 | 8.10 |
| CHEMBL371336 | — | — | 1 | 8.07 |
| CHEMBL196515 | — | — | 1 | 7.70 |
| CHEMBL196492 | — | — | 1 | 7.70 |
| CHEMBL381866 | — | — | 1 | 7.58 |
| CHEMBL197547 | — | — | 1 | 7.54 |
| CHEMBL196162 | — | — | 1 | 7.50 |
| CHEMBL372956 | — | — | 1 | 7.40 |
| CHEMBL196551 | — | — | 1 | 7.37 |
| CHEMBL198654 | — | — | 1 | 7.13 |
| CHEMBL194810 | — | — | 1 | 7.05 |
| CHEMBL436293 | — | — | 1 | 7.03 |
| CHEMBL381016 | — | — | 1 | 6.92 |
| CHEMBL197624 | — | — | 1 | 6.85 |
| CHEMBL198421 | — | — | 1 | 6.71 |
| CHEMBL370176 | — | — | 1 | 6.54 |
| CHEMBL372568 | — | — | 1 | 5.93 |
| CHEMBL194889 | — | — | 1 | 5.92 |
| CHEMBL196589 | — | — | 1 | 5.90 |
| CHEMBL196669 | — | — | 1 | 5.70 |
| CHEMBL371106 | — | — | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL383361 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL198362 | RIVAROXABAN | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL194186 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL364284 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL196539 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL197377 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL370614 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL194193 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL371336 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL196515 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL196492 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL381866 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL197547 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL196162 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL372956 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL196551 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL198654 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL194810 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL436293 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL381016 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL197624 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL198421 | — | IC50 | = | 197.0 | nM | 6.71 |
| CHEMBL370176 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL372568 | — | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL194889 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL196589 | — | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL196669 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL371106 | — | IC50 | = | 2300.0 | nM | 5.64 |