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Assay Detail

CHEMBL880575

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory concentration against soybean lipoxygenase upon incubation with sodium linoleate (0.1 mM) at RT
14
Total Activities
14
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Glycine max
Confidence 9 — Direct single protein target
Curated By Expert

Target

Seed linoleate 13S-lipoxygenase-1 (CHEMBL4586)
Type SINGLE PROTEIN
Organism Glycine max

Publication

Synthesis and antiinflammatory activity of coumarin derivatives.
Kontogiorgis CA, Hadjipavlou-Litina DJ.
J Med Chem (2005) 48 : 6400 -6408
PubMed 16190766 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 4.37 4.89
Inhibition 1 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL197190 1 4.89
CHEMBL193416 1 4.43
CHEMBL196156 1 4.39
CHEMBL195020 1 4.38
CHEMBL51628 UMBELLIFERONE 1 4.37
CHEMBL196052 1 4.36
CHEMBL194961 1 4.33
CHEMBL196527 1 4.28
CHEMBL194450 1 4.23
CHEMBL364885 1 4.00
CHEMBL382756 1 -
CHEMBL436313 1 -
CHEMBL381246 1 -
CHEMBL6466 COUMARIN 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL197190 IC50 = 13000.0 nM 4.89
CHEMBL193416 IC50 = 37000.0 nM 4.43
CHEMBL196156 IC50 = 41000.0 nM 4.39
CHEMBL195020 IC50 = 42000.0 nM 4.38
CHEMBL51628 UMBELLIFERONE IC50 = 43000.0 nM 4.37
CHEMBL196052 IC50 = 44000.0 nM 4.36
CHEMBL194961 IC50 = 47000.0 nM 4.33
CHEMBL196527 IC50 = 52000.0 nM 4.28
CHEMBL194450 IC50 = 59000.0 nM 4.23
CHEMBL364885 IC50 = 100000.0 nM 4.00
CHEMBL382756 IC50 >> 1000000.0 nM -
CHEMBL436313 IC50 >> 1000000.0 nM -
CHEMBL381246 IC50 >> 1000000.0 nM -
CHEMBL6466 COUMARIN Inhibition = 15.1 % -