Assay Detail
Binding
CHEMBL880598
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as radioligand (30 degree C for 2 h, at pH 7.5 with Tris-HCl buffer)
67
Total Activities
67
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepacivirus hominis |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
RNA-directed RNA polymerase (CHEMBL4296320) ↗| Type | SINGLE PROTEIN |
| Organism | Hepacivirus hominis |
Publication
Simple but highly effective three-dimensional chemical-feature-based pharmacophore model for diketo acid derivatives as hepatitis C virus RNA-dependent RNA polymerase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 67 | 5.02 | 7.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL198718 | — | — | 1 | 7.31 |
| CHEMBL372590 | — | — | 1 | 7.25 |
| CHEMBL362185 | — | — | 1 | 7.00 |
| CHEMBL198423 | — | — | 1 | 7.00 |
| CHEMBL196447 | — | — | 1 | 6.96 |
| CHEMBL198813 | — | — | 1 | 6.85 |
| CHEMBL196154 | — | — | 1 | 6.42 |
| CHEMBL369909 | — | — | 1 | 6.17 |
| CHEMBL372359 | — | — | 1 | 6.02 |
| CHEMBL193447 | — | — | 1 | 6.00 |
| CHEMBL426830 | — | — | 1 | 5.85 |
| CHEMBL371987 | — | — | 1 | 5.70 |
| CHEMBL196293 | — | — | 1 | 5.40 |
| CHEMBL196397 | — | — | 1 | 5.34 |
| CHEMBL16326 | — | — | 1 | 5.25 |
| CHEMBL193671 | — | — | 1 | 5.22 |
| CHEMBL197296 | — | — | 1 | 5.20 |
| CHEMBL196621 | — | — | 1 | 5.17 |
| CHEMBL196821 | — | — | 1 | 5.13 |
| CHEMBL371538 | — | — | 1 | 5.12 |
| CHEMBL370821 | — | — | 1 | 5.12 |
| CHEMBL108253 | — | — | 1 | 5.10 |
| CHEMBL197033 | — | — | 1 | 5.09 |
| CHEMBL197557 | — | — | 1 | 5.09 |
| CHEMBL196012 | — | — | 1 | 5.08 |
| CHEMBL365185 | — | — | 1 | 5.00 |
| CHEMBL370131 | — | — | 1 | 4.92 |
| CHEMBL370124 | — | — | 1 | 4.89 |
| CHEMBL199195 | — | — | 1 | 4.89 |
| CHEMBL194466 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL198718 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL372590 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL198423 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL362185 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL196447 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL198813 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL196154 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL369909 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL372359 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL193447 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL426830 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL371987 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL196293 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL196397 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL16326 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL193671 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL197296 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL196621 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL196821 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL371538 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL370821 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL108253 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL197033 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL197557 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL196012 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL365185 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL370131 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL370124 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL199195 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL194466 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL197897 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL198366 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL198879 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL371719 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL199153 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL262732 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL436119 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL197626 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL372525 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL194300 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL194519 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL194572 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL372984 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL197118 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL198878 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL446444 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL197721 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL371867 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL199200 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL380801 | — | IC50 | = | 32000.0 | nM | 4.50 |