Compound Detail
CHEMBL426830
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Basic Information
| ChEMBL ID | CHEMBL426830 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JOSFQGWRSLOEEZ-DHDCSXOGSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
314.3
MW (Da)
2.52
ALogP
5
HBA
3
HBD
104.1
PSA (Ų)
0.43
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.85
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| RNA-directed RNA polymerase CHEMBL4296320 | IC50 | 5.85 | 5.85 | 1400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| RNA-directed RNA polymerase | IC50 | = | 1400.0 | nM | 5.85 | Inhibitory concentration against NS5B HCV polymerase using [alpha-32P]UTP as rad... | 16190757 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16190757 | 10.1021/jm0504454 | RNA-directed RNA polymerase | 1 |
Data from ChEMBL 36 via Core Engine