Assay Detail
Binding
CHEMBL880732
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In vitro binding affinity towards histamine H1 receptor expressed in CHO-K1 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO-K1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
5-lipoxygenase inhibitors with histamine H(1) receptor antagonist activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.04 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL307609 | — | — | 1 | 8.40 |
| CHEMBL1000 | CETIRIZINE | 4.0 | 1 | 7.85 |
| CHEMBL305662 | — | — | 1 | 7.30 |
| CHEMBL73135 | — | — | 1 | 6.82 |
| CHEMBL74688 | — | — | 1 | 6.75 |
| CHEMBL312082 | — | — | 1 | 6.72 |
| CHEMBL73706 | — | — | 1 | 6.26 |
| CHEMBL74779 | — | — | 1 | 6.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL307609 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL1000 | CETIRIZINE | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL305662 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL73135 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL74688 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL312082 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL73706 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL74779 | — | Ki | = | 660.0 | nM | 6.18 |