Assay Detail
Binding
CHEMBL880846
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Inhibitory activity against human Neuronal nitric oxide synthase
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoforms.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.23 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL353794 | — | — | 1 | 6.30 |
| CHEMBL269058 | — | — | 1 | 5.96 |
| CHEMBL306541 | — | — | 1 | 5.50 |
| CHEMBL315857 | — | — | 1 | 5.46 |
| CHEMBL161118 | — | — | 1 | 5.43 |
| CHEMBL158641 | — | — | 1 | 5.17 |
| CHEMBL99636 | — | — | 1 | 5.00 |
| CHEMBL329431 | — | — | 1 | 5.00 |
| CHEMBL158626 | — | — | 1 | 4.77 |
| CHEMBL161318 | — | — | 1 | 4.70 |
| CHEMBL7889 | L-NIL | — | 1 | 4.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL353794 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL269058 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL306541 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL315857 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL161118 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL158641 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL99636 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL329431 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL158626 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL161318 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL7889 | L-NIL | IC50 | = | 61000.0 | nM | 4.21 |