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Assay Detail

CHEMBL880931

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Binding
Binding affinity for human Estrogen receptor beta
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Estrogen receptor beta (CHEMBL242)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

ERbeta ligands. Part 4: Synthesis and structure-activity relationships of a series of 2-phenylquinoline derivatives.
Vu AT, Cohn ST, Manas ES, Harris HA, Mewshaw RE.
Bioorg Med Chem Lett (2005) 15 : 4520 -4525
PubMed 16098741 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 25 7.41 8.47

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL194265 1 8.47
CHEMBL135 ESTRADIOL 4.0 1 8.44
CHEMBL198411 1 8.37
CHEMBL372783 1 8.34
CHEMBL198410 1 8.28
CHEMBL44 GENISTEIN 2.0 1 8.00
CHEMBL191974 1 7.80
CHEMBL371009 1 7.64
CHEMBL198445 1 7.57
CHEMBL197667 1 7.55
CHEMBL196530 1 7.52
CHEMBL198088 1 7.44
CHEMBL197757 1 7.36
CHEMBL198679 1 7.28
CHEMBL198089 1 7.22
CHEMBL440757 1 7.12
CHEMBL198680 1 7.10
CHEMBL196583 1 7.06
CHEMBL371305 1 7.03
CHEMBL59438 1 6.77
CHEMBL196742 1 6.68
CHEMBL197889 1 6.66
CHEMBL198204 1 6.12
CHEMBL372304 1 5.92
CHEMBL196577 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL194265 IC50 = 3.4 nM 8.47
CHEMBL135 ESTRADIOL IC50 = 3.6 nM 8.44
CHEMBL198411 IC50 = 4.3 nM 8.37
CHEMBL372783 IC50 = 4.6 nM 8.34
CHEMBL198410 IC50 = 5.3 nM 8.28
CHEMBL44 GENISTEIN IC50 = 10.0 nM 8.00
CHEMBL191974 IC50 = 16.0 nM 7.80
CHEMBL371009 IC50 = 23.0 nM 7.64
CHEMBL198445 IC50 = 27.0 nM 7.57
CHEMBL197667 IC50 = 28.0 nM 7.55
CHEMBL196530 IC50 = 30.0 nM 7.52
CHEMBL198088 IC50 = 36.0 nM 7.44
CHEMBL197757 IC50 = 44.0 nM 7.36
CHEMBL198679 IC50 = 52.0 nM 7.28
CHEMBL198089 IC50 = 60.0 nM 7.22
CHEMBL440757 IC50 = 75.0 nM 7.12
CHEMBL198680 IC50 = 79.0 nM 7.10
CHEMBL196583 IC50 = 88.0 nM 7.06
CHEMBL371305 IC50 = 93.0 nM 7.03
CHEMBL59438 IC50 = 171.0 nM 6.77
CHEMBL196742 IC50 = 211.0 nM 6.68
CHEMBL197889 IC50 = 221.0 nM 6.66
CHEMBL198204 IC50 = 750.0 nM 6.12
CHEMBL372304 IC50 = 1190.0 nM 5.92
CHEMBL196577 IC50 > 5000.0 nM -