Assay Detail
Binding
CHEMBL880940
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Activity against human platelet microsome Thromboxane synthase
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Thromboxane modulating agents. 3. 1H-imidazol-1-ylalkyl- and 3-pyridinylalkyl-substituted 3-[2-[(arylsulfonyl)amino]ethyl]benzenepropanoic acid derivatives as dual thromboxane synthase inhibitor/thromboxane receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 7.44 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL117752 | — | — | 1 | 7.75 |
| CHEMBL115387 | — | — | 1 | 7.70 |
| CHEMBL326356 | — | — | 1 | 7.66 |
| CHEMBL119670 | — | — | 1 | 7.66 |
| CHEMBL115636 | — | — | 1 | 7.66 |
| CHEMBL114063 | — | — | 1 | 7.57 |
| CHEMBL283656 | DAZMEGREL | 2.0 | 1 | 7.55 |
| CHEMBL113753 | — | — | 1 | 7.54 |
| CHEMBL115806 | — | — | 1 | 7.54 |
| CHEMBL295512 | — | — | 1 | 7.47 |
| CHEMBL116704 | — | — | 1 | 7.43 |
| CHEMBL117538 | — | — | 1 | 7.43 |
| CHEMBL118084 | — | — | 1 | 7.42 |
| CHEMBL114456 | — | — | 1 | 7.42 |
| CHEMBL418852 | — | — | 1 | 7.42 |
| CHEMBL117373 | — | — | 1 | 7.42 |
| CHEMBL324059 | — | — | 1 | 7.41 |
| CHEMBL432958 | — | — | 1 | 7.41 |
| CHEMBL63090 | — | — | 1 | 7.41 |
| CHEMBL117224 | — | — | 1 | 7.37 |
| CHEMBL119035 | — | — | 1 | 7.37 |
| CHEMBL116196 | — | — | 1 | 7.35 |
| CHEMBL47612 | — | — | 1 | 7.32 |
| CHEMBL115805 | — | — | 1 | 7.32 |
| CHEMBL118008 | — | — | 1 | 7.31 |
| CHEMBL117561 | — | — | 1 | 7.28 |
| CHEMBL117294 | — | — | 1 | 7.27 |
| CHEMBL116970 | — | — | 1 | 7.21 |
| CHEMBL320235 | — | — | 1 | 7.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL117752 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL115387 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL326356 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL119670 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL115636 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL114063 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL283656 | DAZMEGREL | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL113753 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL115806 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL295512 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL116704 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL117538 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL118084 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL114456 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL418852 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL117373 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL324059 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL432958 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL63090 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL117224 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL119035 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL116196 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL47612 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL115805 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL118008 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL117561 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL117294 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL116970 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL320235 | — | IC50 | = | 61.0 | nM | 7.21 |