Assay Detail
Functional
CHEMBL881111
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to reverse action of CpG-ODN on WEHI 231 murine B-cell lymphoma cells
51
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | WEHI 231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and activity of substituted 2-phenylquinolin-4-amines, antagonists of immunostimulatory CpG-oligodeoxynucleotides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 51 | 7.80 | 9.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL280148 | — | — | 1 | 9.12 |
| CHEMBL21459 | — | — | 1 | 9.00 |
| CHEMBL22993 | — | — | 1 | 8.91 |
| CHEMBL22884 | — | — | 1 | 8.85 |
| CHEMBL282277 | — | — | 1 | 8.84 |
| CHEMBL25325 | — | — | 1 | 8.84 |
| CHEMBL21965 | — | — | 1 | 8.82 |
| CHEMBL282439 | — | — | 1 | 8.76 |
| CHEMBL21835 | — | — | 1 | 8.70 |
| CHEMBL21756 | — | — | 1 | 8.66 |
| CHEMBL268553 | — | — | 1 | 8.62 |
| CHEMBL281569 | — | — | 1 | 8.49 |
| CHEMBL21945 | — | — | 1 | 8.27 |
| CHEMBL25707 | — | — | 1 | 8.26 |
| CHEMBL21781 | — | — | 1 | 8.17 |
| CHEMBL21352 | — | — | 1 | 8.15 |
| CHEMBL22118 | — | — | 1 | 8.11 |
| CHEMBL278530 | — | — | 1 | 8.04 |
| CHEMBL22086 | — | — | 1 | 7.94 |
| CHEMBL21808 | — | — | 1 | 7.91 |
| CHEMBL21963 | — | — | 1 | 7.88 |
| CHEMBL21810 | — | — | 1 | 7.88 |
| CHEMBL22087 | — | — | 1 | 7.88 |
| CHEMBL277849 | — | — | 1 | 7.86 |
| CHEMBL282886 | — | — | 1 | 7.86 |
| CHEMBL21335 | — | — | 1 | 7.85 |
| CHEMBL21768 | — | — | 1 | 7.81 |
| CHEMBL21950 | — | — | 1 | 7.80 |
| CHEMBL21538 | — | — | 1 | 7.77 |
| CHEMBL416738 | — | — | 1 | 7.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL280148 | — | EC50 | = | 0.7586 | nM | 9.12 |
| CHEMBL21459 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL22993 | — | EC50 | = | 1.23 | nM | 8.91 |
| CHEMBL22884 | — | EC50 | = | 1.413 | nM | 8.85 |
| CHEMBL282277 | — | EC50 | = | 1.445 | nM | 8.84 |
| CHEMBL25325 | — | EC50 | = | 1.445 | nM | 8.84 |
| CHEMBL21965 | — | EC50 | = | 1.514 | nM | 8.82 |
| CHEMBL282439 | — | EC50 | = | 1.738 | nM | 8.76 |
| CHEMBL21835 | — | EC50 | = | 1.995 | nM | 8.70 |
| CHEMBL21756 | — | EC50 | = | 2.188 | nM | 8.66 |
| CHEMBL268553 | — | EC50 | = | 2.399 | nM | 8.62 |
| CHEMBL281569 | — | EC50 | = | 3.236 | nM | 8.49 |
| CHEMBL21945 | — | EC50 | = | 5.37 | nM | 8.27 |
| CHEMBL25707 | — | EC50 | = | 5.495 | nM | 8.26 |
| CHEMBL21781 | — | EC50 | = | 6.761 | nM | 8.17 |
| CHEMBL21352 | — | EC50 | = | 7.079 | nM | 8.15 |
| CHEMBL22118 | — | EC50 | = | 7.762 | nM | 8.11 |
| CHEMBL278530 | — | EC50 | = | 9.12 | nM | 8.04 |
| CHEMBL22086 | — | EC50 | = | 11.48 | nM | 7.94 |
| CHEMBL21808 | — | EC50 | = | 12.3 | nM | 7.91 |
| CHEMBL21963 | — | EC50 | = | 13.18 | nM | 7.88 |
| CHEMBL21810 | — | EC50 | = | 13.18 | nM | 7.88 |
| CHEMBL22087 | — | EC50 | = | 13.18 | nM | 7.88 |
| CHEMBL277849 | — | EC50 | = | 13.8 | nM | 7.86 |
| CHEMBL282886 | — | EC50 | = | 13.8 | nM | 7.86 |
| CHEMBL21335 | — | EC50 | = | 14.13 | nM | 7.85 |
| CHEMBL21768 | — | EC50 | = | 15.49 | nM | 7.81 |
| CHEMBL21950 | — | EC50 | = | 15.85 | nM | 7.80 |
| CHEMBL21538 | — | EC50 | = | 16.98 | nM | 7.77 |
| CHEMBL416738 | — | EC50 | = | 17.38 | nM | 7.76 |
| CHEMBL21568 | — | EC50 | = | 18.2 | nM | 7.74 |
| CHEMBL21630 | — | EC50 | = | 18.62 | nM | 7.73 |
| CHEMBL278552 | — | EC50 | = | 18.62 | nM | 7.73 |
| CHEMBL21664 | — | EC50 | = | 20.89 | nM | 7.68 |
| CHEMBL283344 | — | EC50 | = | 21.38 | nM | 7.67 |
| CHEMBL21617 | — | EC50 | = | 21.88 | nM | 7.66 |
| CHEMBL282714 | — | EC50 | = | 21.88 | nM | 7.66 |
| CHEMBL22615 | — | EC50 | = | 22.39 | nM | 7.65 |
| CHEMBL21754 | — | EC50 | = | 23.99 | nM | 7.62 |
| CHEMBL279496 | — | EC50 | = | 26.92 | nM | 7.57 |
| CHEMBL21933 | — | EC50 | = | 27.54 | nM | 7.56 |
| CHEMBL22020 | — | EC50 | = | 46.77 | nM | 7.33 |
| CHEMBL21542 | — | EC50 | = | 50.12 | nM | 7.30 |
| CHEMBL21635 | — | EC50 | = | 67.61 | nM | 7.17 |
| CHEMBL278528 | — | EC50 | = | 104.71 | nM | 6.98 |
| CHEMBL21353 | — | EC50 | = | 120.23 | nM | 6.92 |
| CHEMBL22027 | — | EC50 | = | 194.98 | nM | 6.71 |
| CHEMBL22017 | — | EC50 | = | 1318.26 | nM | 5.88 |
| CHEMBL21451 | — | EC50 | = | 1819.7 | nM | 5.74 |
| CHEMBL21953 | — | EC50 | = | 3090.3 | nM | 5.51 |