Assay Detail
Binding
CHEMBL881135
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against c-src tyrosine kinase
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
1-Oxo-3-aryl-1H-indene-2-carboxylic acid derivatives as selective inhibitors of fibroblast growth factor receptor-1 tyrosine kinase
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.00 | 5.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL329706 | — | — | 1 | 5.44 |
| CHEMBL101457 | — | — | 1 | 5.40 |
| CHEMBL98447 | — | — | 1 | 5.12 |
| CHEMBL85589 | — | — | 1 | 5.08 |
| CHEMBL99724 | — | — | 1 | 5.02 |
| CHEMBL316567 | — | — | 1 | 4.89 |
| CHEMBL317768 | — | — | 1 | 4.60 |
| CHEMBL323564 | — | — | 1 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL329706 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL101457 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL98447 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL85589 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL99724 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL316567 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL317768 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL323564 | — | IC50 | = | 33000.0 | nM | 4.48 |